PHAGOCYTOSIS OF HAEMOZOIN (MALARIAL PIGMENT) ENHANCES METALLOPROTEINASE-9 ACTIVITY IN HUMAN ADHERENT MONOCYTES: ROLE OF IL-1BETA AND 15-HETE

Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: Role of IL-1beta and 15-HETE

Abstract Background It has been shown previously that human monocytes fed with haemozoin (HZ) or trophozoite-parasitized RBCs displayed increased matrix metalloproteinase-9 (MMP-9) enzyme activity and protein/mRNA expression and increased TNF production, and showed higher matrix invasion ability.The present study utilized the same experimental mode

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Has vaccination alleviated the strain on hospitals due to COVID-19? A combined difference-in-difference and simulation approach

Abstract Background Serious measures, including mass vaccination, have been taken to ensure sufficient hospital capacity during the COVID-19 pandemic.Due to high hospitalization risk in the oldest age groups, most countries prioritized elderly for vaccines.The aim of this study is to broaden the understanding of how vaccination in younger age group

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